| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 가을 (10/06 ~ 10/08, 제주 ICC) |
| 권호 |
39권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Multifunctional yolk-shell type gold nanorattles focused on targeting, chemo-Therapy, Hyperthermia for use in anticancer therapy |
| 초록 |
This study presents multifunctional yolk-shell type gold nanorattles focused on targeting, chemo-therapy, hyperthermia to kill the tumor cells. Gold nanorattles have proven to be promising capsules for drug delivery. In order to enhance the elimination of tumor cells and minimize adverse effect, active targeting, chemo-therapy, and hyperthermia are needed. In this work, tumor specific targeting ligand, folic acid(FA), was used as carrier of doxorubicin. In addition, since gold nanorods (GNRs) in this nanorattles strongly absorb near-infrared (NIR) radiation and produce localized cytotoxic heat upon NIR irradiation, this particles can be used as hyperthermia to efficiently kill tumorigenic cells. In this study, these gold nanorattles could successfully target the cancer cells and decrease the viability of tumor cells. |
| 저자 |
민지홍, 한상원, 정의석, 김민수, 조강희, 국윤민, 고원건
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| 소속 |
연세대 |
| 키워드 |
GNR; LbL
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| E-Mail |
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