| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 봄 (04/14 ~ 04/15, 전경련회관) |
| 권호 | 30권 1호, p.664 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Nano-sized self-assembled polymer vesicle (polymersomes) using amphiphilic di-block copolymer poly(ethylene glycol)-poly(D,L-lactide) for hydrophilic drug delivery |
| 초록 | Amphiphilic polymers self-assemble into a specific structure, expressing their coded information. A novel nano-sized hollow polymer vesicle called polymersome was developed using self-assembly of amphiphilic di-block copolymers. The block copolymers of two biocompatible polymers, poly(ethylene glycol) and poly(D,L-lactide were synthesized by ring-opening polymerization in this study. It has been well described by many researches that amphiphilic polymers self-assemble into micelles. However, it is also demonstrated that by using amphiphilic polymers with smaller hydrodynamic volume ratio of hydrophilic portion, self-assembly of polymersome is thermodynamically favorable while self-assembly of micelle is not. Scanning electron microscope (SEM) images give clear evidence that polymersomes have the hollow structure inside. Confocal microscope and optical microscope were also used to verify the hollow structure of polymersomes. Polymersomes having size from several hundred nanometers to a few micrometers were fabricated. The size of polymersomes was verified that it can be controlled by hydrodynamic volume fraction of copolymer hydrophilic portion. The size of polymersomes also varied with regard to polymersome fabrication methods. Polymersomes showed great resistance to chemical surfactant such as SDS. Polymersomes showed greatly enhanced long-term stability with increased molecular weight of PEG. It seems that polymersomes avoid fusion by steric hindrance effect of PEG. In order to load hydrophilic drugs inside polymersomes, drug-recycling method was used. FITC-Dextran and CF (Carboxyfluorescein) was used as model drugs. Confocal microscope image provides a clear evidence of the loading of the drugs inside the polymersomes. Centrifugation of polymersome-dispersed solution, which is essential process during drug-recycling method, was verified that it does not alter any properties of polymersomes. Release profile of polymersomes from polymers with various composition shows that polymersomes are membrane-controlled reservoir systems. Also, release profile and differential scanning calorimetry (DSC) data show that the glass transition temperature of polymersome is the critical factor which controls the membrane property and the release characteristics of polymersomes. |
| 저자 | 이유한, 박태관 |
| 소속 | 한국과학기술원 |
| 키워드 | polymersome; diblock copolymer; PEG-PDLLA |
