| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 봄 (04/07 ~ 04/08, 대전컨벤션센터) |
| 권호 |
36권 1호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Improvement on Dissolution Rate of Cilostazol with Crospovidone |
| 초록 |
The aim of this study was to improve dissolution rate and controlled release of poorly water-soluble drug, cilostazol, using hydrophilic polymer. We prepared solid dispersed cilostazol with hydrophilic polymer, Plasdone S630, surfactant and Poloxamer 407. SEM and DSC were found that amorphous in solid dispersion. The in vitro release behavior of solid dispersion was presented at simulated gastric fluid (pH 1.2). The release behavior of cilostazol in solid dispersion was improved on dissolution rate with hydrophilic polymer and solid dispersed cilostazol with hydrophilic polymer was sustained release behavior than initial burst release of commercial drug (Pletal®). This studies suggest that this solid dispersion system with hydrophilic polymer controlled poorly water-soluble drug, cilostazol, release behaviors. This research was supported by WCU (R31-20029). |
| 저자 |
임동균, 송병주, 김영운, 조원형, 홍동현, 이동원, 강길선
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| 소속 |
전북대 |
| 키워드 |
Cilostazol; Hydrophilic polymer; Dissolution rate; Pletal®; Crystalline
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| E-Mail |
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