| 학회 | 한국공업화학회 |
| 학술대회 | 2019년 가을 (10/30 ~ 11/01, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 | 23권 2호 |
| 발표분야 | 포스터_화학물질안전·위해성 |
| 제목 | Gene expression in zebrafish embryos following exposure to Nano Ag-PVP and Nano Ag-PVP mixed on Hydra protein |
| 초록 | Hydra magnipapillata cells reduce the toxicity of silver nanomaterials to zebrafish (Danio rerio) embryos. In this study, we investigated whether hydra protein reduce nano-Ag-polyvinylpyrrolidone toxicity during embryogenesis of the nanosensitive organism zebrafish. Protein was extracted from hydra. The experimental conditions were exposure to nano Ag-PVP, hydra protein, nano Ag-PVP mixed on hydra protein during embryo development. We investigated the comparative effects of Nano Ag-PVP mixed on Hydra protein and pure Nano Ag PVP on gene expression in zebrafish embryogenesis. In microarray analysis, several genes involved in intercellular signaling, cell adhesion, involvement of signal transmitter PIP3 formation, and inflammation regulation were differentially expressed according to hydra protein. 'igf1, insl3, tacr3a' genes expression were expressed normal range in embryos exposed to hydra protein mixed nano Ag particles in comparison to the Nano Ag Particles exposed group. |
| 저자 | 하지원, 김은아, 여민경 |
| 소속 | 경희대 |
| 키워드 | Hydra; Nanotoxicity; gene expression; protein |
