| 초록 |
The biotechnology field has identified many new biomolecular drugs, such as peptides, proteins and nucleic acid drugs, such as pDNA, antisense oligonucleotides and siRNA, which act at intracellular sites. However, the effective intracellular delivery of these “fragile” drugs remains a significant challenge. Endocytosis of drug formulations usually results in localization within the endosome, where the predominant trafficking fate is fusion with lysosomes and enzymatic degradation of the biomolecular drug. A variety of pathogens have evolved acid-responsive fusogenic peptides on their surfaces to overcome this barrier by enhancing endosomal escape to the cytoplasm at the acidic pH of the endosome. Inspired by the principle behind this biological strategy, we have designed a biomimetic family of acid-responsive polymeric carriers that enhance escape of fragile drugs from the endosome to the cytosol. |
