| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 봄 (04/10 ~ 04/11, 대전 컨벤션센터) |
| 권호 |
39권 1호 |
| 발표분야 |
의료용 고분자 부문위원회(초청-영어발표/포스터-국문발표 가능) |
| 제목 |
Redox- and pH-sensitive poly(β-amino ester) |
| 초록 |
In this study, we reported the successful synthesis of a novel biodegradable and biocompatible amphiphilic poly(β-amino ester) (PAE) which can self-assemble to form micelle contain a hydrophobic pH-senstive core of PAE and a hydrophilic detachable shell of methyl polyethylene glycol (MPEG). This polymeric micellar system, has average size 120 ± 1.6 nm at physiological condition, can be rapidly destablized and disassembled because of both hydrophobicity decrement of PAE backbone under low pH conditions and reduction of cleavage-linker under the high concentration of reducing agent such as glutathione (GSH). With these properties, this polymer might be potential for delivering poor solubility hydrophobic drugs to intracellular in which loaded-drug will be release at endosome due to low pH (5.5-6.5) or at cytosol due to high concentration of GSH (10 mM) |
| 저자 |
BUI QUANGNAM, 이두성
|
| 소속 |
성균관대 |
| 키워드 |
Redox; pH; micelle; poly(β-amino ester)
|
| E-Mail |
|
