| 초록 |
Paracetamol (or acetaminophen) is a widely used over the-counter analgesic and antipyretic. It is commonly used for the relief of headaches and other minor aches and pains. Paracetamol is known to have three polymorphs: stable formⅠ(monoclinic), metastable formⅡ(orthorhombic), and unstable formⅢ. In this study, by adjusting the degree of supersaturation, crystallization mode (cooling) and operating crystallization conditions(cooling rate): needed polymorphs of paracetamol were selectively crystallized. While 60℃ paracetamol’s saturation solution is cooled to 10℃, double jacket is mesured by in-line Raman spectroscopy. Increasing the cooling rate, metastable formⅡis easily obtained. Using the Raman spectroscopy and X-ray powder diffraction (XPRD), the polymorphic crystals were identified. |
