| 초록 |
The surface nitric oxide (NO) delivery garners paramount importance in various biomedical applications such as anti-restenosis, wound healing, anticancer, and antibacterial. Despite numerous reports for NO-releasing materials which include polymeric micelles, inorganic nanoparticles, dendrimers, peptides, hydrogels, and xerogels, methods to immobilize the NO-releasing materials are under developed. Therefore, developing a general strategy of surface chemistry for NO-immobilization is critical and necessary in future development of NO-releasing medical devices. The key point to achieve these purposes is to find the special surface chemistry which has precursors for NO-releasing moieties and can be formed on a variety of substrates. It has been reported that poly(dopamine) (pDA) and poly(norepinephrine) (pNE), which form chemically active adherent thin films through oxidative self-polymerization, can show the material-independent coating ability with secondary amino groups. We hypothesized that this secondary amino group could be functionalized by 1-substituted diazen-1-ium-1,2-diolates (diazeniumdiolates) which is generally installed at secondary amino groups and spontaneously dissociates under physiological conditions to release two equivalents of NO from each functional group. In this presentation, we present the first report of a facile, versatile, and biocompatible strategy for surface NO delivery utilizing catecholamines, functionalized with diazeniumdiolates. |
