| 초록 |
Nitric oxide (NO) has been emerged as an important signaling molecule for the control of tumor progression. Recent researches have shown that the potential of NO in a direct use as an apoptotic agent or in combination with chemotherapeutic agents to enhance its therapeutic activity for a variety of cancers. However, the direct delivery of NO to tumor cell is difficult, because NO has an extremely short half-life in the body. In this study, we developed S-nitrosoglutathione (GSNO)-conjugated self-assembled hyaluronic acid nanoparticles for intracellular NO delivery. The nanoparticle would enhance the stability of GSNO at an intracellular compartment. In contrast, the nanoparticles would degrade by hyaluronidases-1 (Hyal-1) at the cytosol of tumor cells to allow the facilitated intracellular generation of NO. The NO from degraded hyaluronic acid–based nanoparticles by Hyal-1 may synergistically enhance the anticancer activity of doxorubicin (DOX). |
