| 초록 |
With considerable efforts of many researchers on the role of nitric oxide (NO) in biological system, it has been well known fact that nitric oxide has a diversity of functions including cardiovascular homeostasis, wound healing, antibacterial activity and anticancer effect. These versatile functions of NO mainly depend on its concentration and duration. For example, cardiovascular homeostasis and wound healing could be worked when NO releases at low concentration for long time. Meanwhile release of NO with high concentration and short time causes antibacterial activity and anticancer effect. Therefore development of a rational NO delivery system which suited each function has been one of the significant issues in biological applications. Here in, we describe PEG based ointment containing NO-releasing polymer to get wound healing effect due to the sustainable release of NO from the prepared ointment. NO-releasing polymer is composed of thermosensitive Pluronic F127 having good biocompatibility and branched polyethylenimine (BPEI) housed N-diazeniumdiolates (NONOates) which could store and release NO under appropriate physiological condition. PEG-based ointment plays a role as a storage of NO-releasing polymer and moisturizer to help enhance wound healing effect. |
