| 초록 |
In biomedical applications, nanofibers have enabled controlled delivery of active materials in unprecedented ways. However, in vivo situations, the advanced systems of nanofibers always require surgery instead of simple injection for the delivery of active materials. In our studies, we proposed to develop electrospun non-woven nanofibers mats entrapped within microparticles, which can be injected. Nanofiber-containing pH-dependent microhydrogels were developed through a combination of normal electrospinning and spraying. The mixture of solvents & dissolution time control parameters can employ important role to dissolve out unentrapped PLA electrospun nanofibers within microhydrogels by using vacuum filtration method. The physically sprayed microparticles were ionically crosslinked with aqueous calcium chloride. Optical microscopy revealed uniform surfaces and smooth structures (bead free) with microhydrogels entrapped PLA nanofibers. It concludes that 60 mins of ionic crosslink gives perfectly entrapped microhydrogels on the nanofibers. The shorter dissolution time gives maximum no. of nanofibers within microhydrogels as compared longer dissolution time. This work suggests one possible approach for multiple on-off drug release or cell encapsulations of such actives using microarchitectures. The combination of electrospinning and normal spraying seems to be a useful technique for the preparation of microarchitectures and the combination of two nanomaterials. |
