| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 봄 (04/14 ~ 04/15, 전경련회관) |
| 권호 | 30권 1호, p.271 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Preparation of double-walled microspheres of biodegradable poly(L-lactide-co-glycolide) with dextran using oil-in-water(O/W) solvent evaporation method |
| 초록 | Double-walled spheres play an important role in controlled drug delivery for pharmaceutical application, because of the low initial burst compared with single-walled spheres and targetable delivery to specific organ. But it has drawback in loading drug and controlling size.1-3 In this study, we fabricated double-walled spheres using oil-in-water(O/W) solvent evaporation method with/without ultrasonication and investigated the size variation of spheres according to the contents of poly(lactide-co-glycolide)(PLGA). Double-walled spheres were characterized by Scanning elecron microscope (SEM), and confocal fluorescence laser microscope (CFLM). Microspheres showed smooth surface and obvious border between core and corona by using SEM observation. We observed the fluorescent core in the double-walled spheres composed of FITC-dextran and PLGA using CFLM. As shown in CFLM analysis, it was found that the core of the fabricate microsphere was dextran and the corona of the fabricate microsphere was PLGA. As the concentration of PLGA was more increase , the size of spheres was more increase. Acknowledgement : This research was supported by Establishment of Nanoscopia Center of Excellence (KMOST) (a) (b) Figure 1. The microscopic observation (a) SEM image of microsphere (cross-section, × 60) and (b) CFLM of microsphere (× 200) Reference 1. S. Freiberg and X. X. Zhu, Inter J Pharm., 282, 1 (2004) 2. Y. Y. Yang, M. Shi, S. H. Goh, S. M. Moochhala, S. Ng and J. Heller, J. Control. Rel., 88, 201 (2003) 3. K. D. Hong, Y. S. Ahn, J. T. Go, S. H. Cho, S, H, Yuk, H, S. Shin, J. M. Rhee, and G. Khang, Polymer (Korea), submitted (2005) |
| 저자 | 고종태, 양대혁, 박기숙, 하현정, 최방실, 신형식, 이종문, 강길선 |
| 소속 | 전북대 |
| 키워드 | double-layered microspheres; PLGA; dextran; O/W solvent evaporation |
