| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 가을 (10/13 ~ 10/14, 제주 ICC) |
| 권호 | 30권 2호 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | The effect of surfactants in double-layered microspheres using oil-in-water(O/W) solvent evaporation method |
| 초록 | To develop the preparative method for poly(lactide-co-glycolide)-based micro·nanospheres containing proteins or drugs, and the surfactants play an important role in formed double-layered microspheres for pharmaceutical application.1~2 In this study, we fabricated double-layered microspheres using oil-in-water (O/W) solvent evaporation method with/without ultrasonication and investigated the specific character of double-layered microspheres according to the kind of surfactants. Double-layered microspheres were characterized by scanning elecron microscope (SEM), fourier transform infrared spectroscopy (FT-IR), nuclear magnetic resonance (NMR), camscope. Double-layered microspheres showed various size and form according to kinds of surfactants by using SEM observation. And we observed specific peeks of PLGA and dextran at once using NMR, FT-IR. In NMR, FT-IR analysis results, we confirmed coexistence of dextran and PLGA in double-layered microspheres. Acknowledgement : This research was supported by Establishment of Nanoscopia Center of Excellence (KMOST) Reference 1. K. D. Hong, Y. S. Ahn, J. T. Ko, S. H. Yuk, H. S. Shin, J. M. Rhee, G. Khang, and H. B. Lee, Polymer (Korea), 29, 260 (2005) 2. T. Ouchi, M. Sasakawa, H. Ariura, M. Toyohara, and Y. Ohya, Polymer, 45, 1583, (2004) |
| 저자 | 고종태1, 이재호1, 윤주용1, 박정수1, 육순홍2, 신형식1, 이종문1, 김문석3, 이해방3, 강길선1 |
| 소속 | 1전북대, 2한남대, 3한국화학(연) |
| 키워드 | double-layered spheres; PLGA; surfactant; O/W |
