| 초록 |
There has been increasing interest in stimuli-responsive polymers over the last few decades. Among them, polymer systems that undergo a nanoaggregation in response to biological temperature and pH have been widely investigated for gene and tumor targeting delivery. In this work, amphiphilic polyaspartamide(PASAM) derivatives were synthesized by successive aminolysis reactions of polysuccinimide using both alkylamine and substituted-aminoethyl amines, and the resulting polymers were investigated as biodegradable stimuli-responsive polymers or gels, possessing self-aggregation behavior through LCST or/and sol-gel transition in response to biological conditions. The prepared thermo and pH responsive PASAM derivatives are potential candidates in the design of novel drug carriers for intracellular or tumor targeting drug delivery which require a triggered system at very small temperature and pH changes in the physiological environment. |
