| 초록 |
Streptomyces is a prominent source of novel natural products with medicinal and industrial values. Among various approaches of systems biology, genome-scale metabolic models (GEMs) have shown to be effective in predicting comprehensive metabolic phenotypes in terms of fluxes in a target cell. In this study, GEMs were reconstructed for a total of 242 Streptomyces strains through an automatic pipeline, and pan-reactome analysis was conducted using the 242 GEMs to characterize important metabolic phenotypes of these Streptomyces species. Pan-reactome analysis revealed innate diversity of metabolic contents of the Streptomyces species, especially those associated with biosynthesis of secondary metabolites. Metabolic phenotypes examined using the 242 Streptomyces GEMs include growth capability under a wide range of media conditions, gene essentiality, and biosynthetic capability of secondary metabolite precursors. GEMs reconstructed for the 242 Streptomyces strains and insights from the pan-reactome analysis will serve as a useful source for our better understanding of this important group of bacteria. |
