| 초록 |
In recent years, one of the major issues in clinical and medical science is accurate diagnose of carcinoma. In order to advance the technology, the pursuit of labeling-free stimuli-responsive polymers has been considered to be an essential requirement for the achievement of efficient tumor cell sensing, on account of a wide range of availability. Particularly, the acidic characteristics of tumor cells lead researchers to investigate pH-responsive polymers towards the development of label-free tumor cell sensors. In present study, we synthesized a new set of pH-responsive conjugated-polymers for in-vivo tumor cells sensing. The systems exhibited intriguing pH-responsive turn-off fluorescence properties in the presence of tumor cells while the signals were recovered upon exposure to basic environments. The fluorescent properties were revealed to be not significantly affected by common salt in biological system, implying the stable utilization of our polymers for in-vivo experiments. |
