| 학회 |
한국공업화학회 |
| 학술대회 |
2019년 가을 (10/30 ~ 11/01, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
23권 2호 |
| 발표분야 |
포스터_고분자 |
| 제목 |
Synthesis of AB2-type miktoarm poly(L-lactide)-b-poly(N-acryloylmorpholine) amphiphilic star block copolymers as nanocarriers for drug delivery |
| 초록 |
In the present study, a series of amphiphilic AB2-type miktoarm star block copolymers consisting of hydrophobic poly(L-lactide) (PLLA) as a A arm and hydrophilic poly(N-acryloylmorpholine) (PNAM) as two B arms were synthesized via the combination of ring opening polymerization and xanthate-mediated reversible addition-fragmentation chain transfer polymerization. Resultant polymers were analyzed by 1H NMR spectroscopy and gel permeation chromatography. Aggregation properties of the amphiphilic miktoarm star block copolymers were studied by fluorescence spectroscopy, transmission electron microscopy and dynamic light scattering. Doxorubicin (DOX)was successfully loaded into the miktoarm star block copolymer micelles.The result revealed that DOX release was enhanced as the pH reduced from 7.4 to 6.4. |
| 저자 |
Kalyan Ramesh, Sonita A.P. Siboro, 박찬, 임권택
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| 소속 |
부경대 |
| 키워드 |
Miktoarm block copolymer; RAFT polymerization; ROP polymerization
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| E-Mail |
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