| 초록 |
Small interfering RNA has been considered as one of the most promising therapeutics for various diseases such as cancers and infections as well as genetic diseases. However, its innate drawbacks from the lability against external environment to structural vulnerability owing to the short persistent length with low charge density make it difficult to be adopted in clinical trials. Thus, it is believed that how to overcome those shortcomings and transport siRNAs into the cell safely are the most significant issues in siRNA drug development. In that sense, a myriad of carriers such as cationic polymers, lipids, peptides and micelles are exploited as well as several types of engineered siRNA structure such as a multimeric siRNA1, PEG conjugated siRNA3 and siRNA conjugate micelle structures3 are also studied intensively. Here, we suggest a novel structure of siRNA polymer conjugates using neutral dextran polymer. |
