| 초록 |
Small interfering RNA (siRNA) of 21 base pair can suppress a target gene selectively at the mRNA level by a process called RNA interference (RNAi). Synthetic siRNA has considered a new class of nucleic acid drug for treatment of various diseases, including viral infection and cancer. Despite the high therapeutic potential of siRNA, safe and efficient delivery problems are major hurdles to clinical applications. In our previous study, multimeric siRNA chemically crosslinked produced more stable polyelectrolyte complex with less toxic carriers and showed enhanced gene silencing efficiency because of increased charge densities and flexibilities. Here, we introduced streptavidin molecules into the multimeric siRNAs to incorporate various functionalities. We expect that the system can be easily modified with a variety of biotin containing molecules for targeting and imaging. |
