| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 봄 (04/12 ~ 04/13, 대전컨벤션센터) |
| 권호 |
37권 1호 |
| 발표분야 |
대학원생 구두발표 |
| 제목 |
Reducible Dextran-siRNA Conjugates for Stabilization, Tumor-targeting, and Efficient Gene Silencing |
| 초록 |
Small interfering RNA (siRNA) has been considered as a very attractive therapeutic alternative to chemical-based medicines; however, their chemical and biological instability and poor delivery efficiency often limit the wide use for clinical applications. Here we report a self-assembled polyelectrolyte complex based on dextran-siRNA conjugates linked via reductively cleavable disulfide bonds. The conjugates were ionically complexed with linear polyethylenimine to a colloidal nanoparticle of about 200 nm in diameter. Dextran-siRNA conjugates provide effective structural features for stabilization and intracellular delivery of siRNA therapeutics. We expect that DSC can further improve siRNA delivery system not only by cationic polymeric cargos but by various nanoparticulate carriers. |
| 저자 |
김지선, 오미화, 박재윤, 남윤성, 박태관
|
| 소속 |
KAIST |
| 키워드 |
siRNA; dextran; linear polyethylenimine; green fluorescence proteins; nanoparticle; folic acid
|
| E-Mail |
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