| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 봄 (04/08 ~ 04/09, 대전컨벤션센터) |
| 권호 |
35권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Improvement of Pranlukast Dissolution by Hydroxypropyl Methylcellulose |
| 초록 |
To overcome solubility of poorly water soluble drugs pranlukast, we prepared solid dispersion by using spray dryer. This solid dispersions formulated using HPMC as a carrier for the solid dispersion, and Meglumine as a surfactant for preventing recrystalline of nano solid disperion. Characterization of nano solid dispersion analyzed by SEM, particle size analyzer, DSC, XRD and FT-IR. The in vitro test was carried out to find improvement of dissolution rate of nano solid dispersion in intestinal juice(pH 6.8), controlled experiment compared pranlukast solid disperion with conventional drugs(Onon). We definite that the solubility of solid dispersion is higher than conventional drug. This studies displayed improvement of dissolution of prepared solid dispersion by using spray drying, poorly water soluble of pranlukast as orally pharmaceutical formulation. |
| 저자 |
조원형, 이영현, 송병주, 조한수, 홍동현, 오명준, 유석철, 유일수, 이동원, 강길선
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| 소속 |
전북대 |
| 키워드 |
Pranlukast; solid dispersion; HPMC; spray-drying
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| E-Mail |
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