| 학회 | 한국공업화학회 |
| 학술대회 | 2019년 가을 (10/30 ~ 11/01, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 | 23권 2호 |
| 발표분야 | 포스터_생체재료 |
| 제목 | Photochemical internalization for overcoming cancer drug resistance |
| 초록 | Cancer chemotherapy has become increasingly utilized, but traditional anticancer drug was gradually caused drug resistance. The major mechanism of drug resistance was the expression level of P-glycoprotein(P-gp), which one of the energy dependent drug efflux pump. Most anticancer drugs are substrates for this transport system by the substrate-binding region of P-gp, decreasing cellular uptake. To overcome drug resistance, we developed polymeric micelle based on nonionic triblock copolymer conjugated photosensitizers and loaded with anti-cancer drug. Photochemical internalization (PCI) is a light triggered strategy to breakdown of the cellular membrane, so the drug loaded micelle are collapsed by reactive oxygen induced lipid peroxidation. This system significantly improves chemotherapeutic efficiency in drug resistant cancer cells. Further, we have expected for this study to represent a potential platform for cancer chemotherapy. |
| 저자 | 이상희1, 나건1, 박우람2, 박형1 |
| 소속 | 1가톨릭대, 2차의과대 |
| 키워드 | photocynamic therapy; photosensitizer; cancer; drug resistance |
