| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 가을 (10/08 ~ 10/09, 광주과학기술원 오룡관) |
| 권호 |
34권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Preparation of size tunable hydrophobically modified poly(γ-glutamic acid) nanoparticles and evaluation of activity as a vaccine adjuvant |
| 초록 |
We prepared size tunable amphiphilic poly(amino acid) nanoparticles (NPs) to evaluate the effects of particle size on dendritic cell (DC) uptake of NPs and their immune stimulatory activities as delivery carriers and adjuvants. The DC uptake of small-sized NPs was lower than the larger sized NPs, but the effect of DC activation by NPs was high in the small sizes. The result would provide guidelines for adjuvant design in the development of an effective vaccine. |
| 저자 |
김형진 |
| 소속 |
Osaka Univ. |
| 키워드 |
nanoparticles; size control; dendritic cell; vaccine adjuvant; drug delivery system
|
| E-Mail |
|
