| 초록 |
Poly(ethylene glycol)s, PEGs, are unique in their material properties such as biocompatibility, non-adhesive property and water-solublizing property, which are extremely useful for a variety of biomedical applications. Surface modifications using PEG has shown to decrease protein adsorption and platelet or cell adhesion on biomaterials. Also PEG graft with anionic sulfonate terminals has been recently proved to enhance the blood compatibility by means a synergistic effect of the dynamic mobility of PEG chains and the negatively charged sulfonate groups. Various different types of functional PEG with specific functionality at one or both chain ends have been synthesized for many specialized applications. In the present work, we are interested in the preparation of telechelic PEG with sulfonate and a polymerizable methacryloyl group at the each end of PEG chain. From the PEG macromonomer, the syntheses of homo- and copolymers possessing a certain degree of sulfonated PEG graft are possible to identify new biocompatible materials for blood-contacting devices. In addition, studies on the preparation and characteristics of novel hydrogel materials containing this sulfonate-end PEG are currently under investigation.
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