| 초록 |
Recently, polydimethylsiloxane (PDMS) particles gained the attention as a polymeric matrix support for biomolecules and contrast agents due to their biocompatible, inert, and tolerance to a variety of fabrication methods. In this study, we synthesized the colloidal nanoparticles (NPs) with various monodisperse size distributions. Modified Stöber process has been tested to synthesize PDMS NPs by using dimethylsiloxane and tetraethyl orthosilicate as precursors. Ammonia was used to induce base-catalyst hydrolysis and condensation, forming dispersed nanocolloids. Chemical bond structure of PDMS was confirmed by FT-IR spectrums and EDS. The synthesized PDMS NPs exhibited an excellent colloidal stability in water. The particle size was readily tunable from approximately 90 nm to 300 nm in diameter by changing the concentration of monomers and catalyst. Furthermore, the cytotoxicity of siloxane-based PDMS NPs was evaluated by CCK-8 assay for all groups. |
