| 초록 |
Nucleic acid-based nanotechnologies have been developed with the base pairing property and applied to numerous bioengineering fields of study. As a novel engineering material, DNA has been used to fabricate nanostructures from simple 2D structures to complex 3D structures. With this development of DNA nanoarchitecture, enzymatic replication technique has been also attracted as a new strategy for building nucleic acid-based nanostructures. Here, DNA nanosphere (DNANS) is fabricated by rolling circle amplification (RCA) and coated with antibodies for target cells detection. DNANS can be applied as a barcode system which can distinguish the tumor cells by recognizing tumor-specific protein. As a proof of concept, the capability for target detection of DNANS barcode system was demonstrated. This target-specific antibody-coated DNANS suggests a new route for the simple and selective recognition of cancer cells. |
