| 학회 | 한국공업화학회 |
| 학술대회 | 2019년 가을 (10/30 ~ 11/01, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 | 23권 2호 |
| 발표분야 | 포스터_생체재료 |
| 제목 | Tannin-based nanoparticles for drug delivery and biosensing |
| 초록 | Tannin derivatives have emerged as nano-carriers of therapeutic agents due to anti-oxidant, anti-radical, and anti-cancer properties in addition to high drug loading efficiency. Herein, we employed tannin as a molecular glue that links hydrophilic poly(ethylene glycol) (PEG) and hydrophobic anticancer drugs to form therapeutic nanoparticles. The synthesis of nanoparticles was simple; vigorous mixing of PEG in water and tannin/drug in ethanol produced nanoparticles through intermolecular assembly via hydrogen bonding and π-π stacking. The synthesized particles showed high drug loading efficiency and pH-responsive release profile. In addition, antibodies could also simply complex with tannin without additives, enabling targeted therapeutic delivery and biosensing applications. **This work was carried out with the support of “Cooperative Research Program for Agriculture Science and Technology Development (Project No. PJ01323201)” Rural Development Administration, Republic of Korea. |
| 저자 | 김지연, 문해람, 홍선기 |
| 소속 | DGIST |
| 키워드 | Tannin; nanoparticle; drug delivery; ROS scavenging |
