| 학회 |
한국고분자학회 |
| 학술대회 |
2003년 봄 (04/11 ~ 04/12, 연세대학교) |
| 권호 |
28권 1호, p.180 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Drug Delivery System Based on Poly(ethylene glycol) methyl ether/Poly(ε-caprolactone) Star-shaped Block Copolymers |
| 초록 |
Micelles from amphiphilic block copolymers are of great interest as promising drug carriers and have been studied extensively. Amphiphilic star-shaped block copolymers composed of poly(ethylene glycol) methyl ether (MPEG) and poly(ε-caprolactone) (PCL) were synthesized by coupling reaction of diblock copolymer (MPEG-b-PCL). Critical micelle concentration (CMC) and size distribution of micelle were determined by Fluorescence Spectroscopy and Dynamic Light Scattering. The number of chain of star-shaped block copolymers participated in the forming micelle was higher than that of diblock copolymers in dilute solution. Pyrene as a typical model drug was incorporated into the hydrophobic inner core of these micelles. Drug loading efficiency (DLE) of star-shaped block copolymers with that of the diblock copolymers was compared. DLE of star-shaped block copolymers showed a marked increase over that of diblock copolymers. The micelle size and DLE were changed with the hydrophobic chain length. The controlled in vitro release behavior showed sustained release characteristics. |
| 저자 |
최국화;김건형;안철희;조원호 |
| 소속 |
서울대 |
| 키워드 |
star-shaped block copolymer; DLE
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| E-Mail |
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