| 초록 |
In this work, chitosan-based functional biomaterial for diltiazem (DTZ) recognition are prepared by using chitosan, PVA, glutaraldehyde (GA), and plasticizers. The functional biomaterial was synthesized by using UV curing process. The surface morphology of the prepared biomaterials was characterized by scanning electron microscope (SEM). In addition, tensile strength (TS), elongation at break (%E), swelling behavior (SB) and solubility (S) for chitosan-based functional biomaterial were investigated. To evaluate the binding characteristics of biomaterial with/wthout DTZ, the adsorption properties was investigated by equilibrium binding experiment. The results indicate that the prepared functional biomaterial have one site of DTZ as the target molecule. As the results of drug release of DTZ with the pH and temperature, the release in high pH and temperature was better than in low pH and temperature. In addition, the release of DTZ was carried out by using artificial skin. |
