| 학회 | 한국화학공학회 |
| 학술대회 | 2012년 봄 (04/25 ~ 04/27, 제주 ICC) |
| 권호 | 18권 1호, p.330 |
| 발표분야 | 분리기술 |
| 제목 | Preparation of inclusion complex of cetirizine dihydrochloride using β-cyclodextrin by aerosol solvent extraction system(ASES) process |
| 초록 | Cetirizine dihydrochloride (CTZ) is antihistamine selectively blocking histamine (H1)-receptor and has effect on easing allergy. Even though CTZ has been used widely, there are difficulties in swallowing and access to water because of strong bitter taste. In this works, bitter taste of CTZ is blocked by preparation of the inclusion complex using β-cyclodextrin(β-CD) by aerosol solvent extraction system(ASES). Since cyclodextrins(CDs) has favorable structure, it is very convenient to make the inclusion complex and complexation can modify the physicochemical and biopharmaceutical properties of CTZ such as bioavailability, chemical stability, unpleasant odor or taste. ASES for complexation of CTZ and β-CD is carried out using dimethylsulfoxide(DMSO) and various ratio of β-CD. We fabricated bitter taste blocked CTZ through taste perception test and the successful complexation is investigated by 1H-NMR, 2D-ROESY, FT-IR, PXRD, FE-SEM, and PSA. |
| 저자 | 손원수1, 이춘원1, 김수정1, 윤용석1, Edward Widjojokusumo1, 이영호1, 김재훈2, 이윤우1, Raymond R. Tjandrawinata3 |
| 소속 | 1서울대, 2한국과학기술(연), 3Dexa Laboratories of Biomolecular Sciences (DLBS) PT Dexa Medica |
| 키워드 | Cetirizine; Inclusion complex; β-cyclodextrin; Supercritical CO2; Supercritical antisolvent; masking taste |
| 원문파일 | 초록 보기 |
