| 학회 | 한국고분자학회 |
| 학술대회 | 2004년 가을 (10/08 ~ 10/09, 경북대학교) |
| 권호 | 29권 2호, p.653 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | In Situ Acrylic Acid Grafting onto PLLA Films and Dual Pore Scaffolds by Direct Plasma Treatment for Tissue Engineering |
| 초록 | Poly-L-lactic acid (PLLA) has been used to prepare PLLA films and scaffolds to guide tissue regeneration in the tissue-engineered field. However, one of the limitation to the use of PLLA as an ideal biomaterial is its high hydrophobicity. To improve the hydrophilicity of PLLA films and scaffolds, hydrophilic monomers having carboxylic acid were grafted onto PLLA film surfaces through the plasma treatment and thermal polymerization. In this study, in situ graft polymerization of acrylic acid (AA) was carried out in the plasma chamber onto PLLA film and dual pore scaffold surfaces that were pretreated with argon plasma treatment by using various methods (Fig. 1 and Table 1). The resulting AA-grafted PLLA films were characterized by water contact angle measurements, ATR-FTIR, ESCA, AFM, and -COOH content by Toluidine Blue O.1 Table 1 shows the water contact angles and the amount of carboxylic acid on AA-grafted PLLA films. As compared to PLLA control and thermal polymerization of AA, AA-grafted PLLAs displayed more hydrophilic surfaces and AA contents were considerably influenced by plasma treatment and reaction conditions. In the cell-material interaction, AA-grafted PLLA films and scaffolds demonstrated greatly improved cell adhesion and spreading as compared with the untreated PLLA ones.2 Therefore, the functional PLLA films and scaffolds with carboxylic acid grafted directly by in situ plasma treatment may be used as cell compatible matrix for tissue engineering. Fig. 1. AA-grafted PLLA films and dual pore scaffolds by plasma treatment. Table 1. Water contact angles and carboxylic acid contents of AA-grafted PLLA films References 1. B. Gupta, J. G. Hilborn, I. Bisson, and P. Frey, J. Appl. Polym. Sci., 81, 2993-3000 (2001). 2. Y. Wan, J. Yang, J. Yang, J. Bei, and S. Wang, Biomaterials, 24, 3757-3764 (2003). |
| 저자 | 양희석1, 안광덕1, 김병수2, 한동근1 |
| 소속 | 1한국과학기술(연), 2한양대 |
| 키워드 | tissue engneering; PLLA; scaffold; plasma treatment; AA grafting |
