| 학회 | 한국고분자학회 |
| 학술대회 | 2004년 가을 (10/08 ~ 10/09, 경북대학교) |
| 권호 | 29권 2호, p.658 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Sustained release of doxorubicin from anionic liposomes in chitosan hydrogel |
| 초록 | The aim of this study was to investigate the release properties of doxorubicin from anionic liposomes in chitosan hydrogel. This chitosan solution containing liposome formed a cross-linked hydrogel at the physical temperature with pH 7.4.1 The release profile of doxorubicin was determined by measuring the fluorescence intensity using fluorescence spectrophotometry with changing temperature and time. These results indicate that the release of doxorubicin from liposome in chitosan hydrogel showed sustained-release as a function of time. This dosage form, chitosan hydrogel, will be applicate to release the drug at specific tumor site as a depot system. Fig. 1. Release profiles of doxorubicin with time. Reference 1.A. Chenite, M. Buschmann, D. Wang, C. Chaput, N. Kandani, Carbohydr Polym 46, 39 (2001). |
| 저자 | 남다은1, 한희동2, 김승수2, 신병철2 |
| 소속 | 1충북대, 2한국화학(연) |
| 키워드 | chtosan; liposome; doxorubicin |
