| 초록 |
We have prepared hybrid nanomaterials for potential drug delivery system utilizing biocompatible hydrogels and 2-dimensional layered metal hydroxide (LMH) nanoparticles; hydrogels are frequently utilized as topical drug delivery and LMHs are known as potential reservoir for controlled drug release. We tried electrophoretic synthesis route to prepare homogeneous hybrid of hydrogels and inorganic nanoparticles. Hydrogels, either agarose or gelatin (1 ~ 2 % in Tris-Cl buffer of pH 7.4) was located in the center of electrophoresis chamber separating cationic solution at anode and base solution at cathode, respectively. Various composition of metal precursors solutions, such as Ni2+/Al3+, Ni2+/Ga3+, Zn2+/Al3+, and Zn2+ were tested in preparing hybrids between hydrogel and layered nanoparticles such as Ni2Al(OH)6(CO3)0.5, Zn2Al(OH)6(CO3)0.5, Zn5(OH)6(CO3)0.5 and etc. According to the X-ray diffraction (XRD) patterns, X-ray absorption spectrum (XAS) and infrared spectra, it was exhibited that the hybrid material has nanoscipic domains having LMH particles in hydrogel matrix and that the crystal structures of nanoparticles are almost similar to that of conventionally prepared ones. The scanning electron microscopy (SEM) images revealed that the electrophoretically prepared hybrids have more homogeneous dispersion of nanoparticles in hydrogel matrix compared with simple mixture of nanoparticles and hydrogels. In order to investigate the potential of the prepared hybrids as drug delivery systems, we loaded polyphenol molecules into the hybrid materials by soaking it in solution and evaluated the time-dependent release patterns of polyphenol. As a result, the hybrids showed controlled drug release patterns compared with hydrogel matrix or nanoparticle itself. |
