| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 봄 (04/08 ~ 04/09, 대전컨벤션센터) |
| 권호 |
35권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Controlled Release of Rosiglitazone maleate by Solid Dispersion with Cellulose Acetate |
| 초록 |
Solid dispersion is usually used to improve the solubility of water insoluble drug. However in this study solid dispersion used to slow initial burst of rosiglitazone maleate. We used celluloses acetate which is used waterproof coat to control release. The solid dispersion of the two components(rosiglitazone maleate and cellulose acetate) were prepared using a spray-dryer. We analyzed surface of solid dispersed sample by scanning electron microscope(SEM) and X-ray diffraction(XRD) was used to analyze the crystallinity. Also the change of structure and crystallinity characteristic of solid dispersion were analyzed by fourier-transform infrared spectroscopy(FT-IR). FT-IR, DSC and XRD results demonstrated that chemical structure and crystallinity were changed by solid dispersion. Release profile showed that release rate of drug decreased, as polymer content rate increase in gastric juice(pH 1.2). This research was supported by WCU(R31-20029) |
| 저자 |
이은용, 김수진, 오명준, 홍민성, 이동원, 강길선
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| 소속 |
전북대 |
| 키워드 |
Rosiglitazone; solid dispersion; spray-drying; cellulose acetate
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| E-Mail |
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