| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 가을 (10/13 ~ 10/14, 제주 ICC) |
| 권호 | 30권 2호 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Synthesis and Characterization of Biodegradable MethoxyPoly(ethyleneglycol)-poly(ε-caprolactone-co-L-lactide) Block Copolymers |
| 초록 | Biodegradable polyesters such as ε-caprolactone (ε-CL) and L-lactide (LA) is an attractive polymer which can be used as a synthetic biomaterial or controlled drug release matrix due to its good biodegradability and biocompatibility. Poly(ethylene glycol) presents outstanding physico-chemical and biological properties, including higher hydrophilicity, solubility in water, lack of toxicity, absence of antigenicity and immunogenicity. In this study, a series of methoxypoly(ethyleneglycol) (MPEG)-poly(ε-caprolactone-co-L-lactide) (PCLA) diblock copolymers were synthesized by ring-opening polymerization of a mixture of ε-caprolactone and L-lactide with different ratios in presence of Sn(Oct)2. The characterization of MPEG-PCLA diblock copolymers were examined by 1H-NMR, GPC, DSC, and XRD. We investigated that kinetics for the ring-opening polymerization of monomer mixtures were carried out in various condition such as a variation with polymerization time, amount of catalyst, and temperature. Also, to examine the biodegradability of MPEG-PCLA diblock copolymers in 20 wt% aqueous solution with the passage of time was prepared diblock copolymers solution using phosphate buffered saline and kept at 37.5 oC for 14 weeks. The biodegradability of MPEG-PCLA diblock copolymers increased as relative L-lactide contents in diblock copolymers increased. In conclusion, we can controll the biodegradability of MPEG-PCLA diblock copolymers related to ratio of PCL and PLA block segments. Acknowledgement : This work was supported by KMOHW (0405-BO01-0204-036) References 1. G. Khang, J. H. Lee, J. W. Lee, J. C. Cho, and H. B. Lee, Korea Polymer J., 8, 80 (2000). 2. K. S. Seo, S. K. Jeon, M. S. Kim, S. H. Cho, H. B. Lee, and G. Khang, Polymer(Korea), 28, 232 (2004). |
| 저자 | 현훈1, 김문석2, 조선행2, 이해방2, 강길선1 |
| 소속 | 1전북대, 2한국화학(연) |
| 키워드 | MPEG-PCLA; ε-caprolactone; L-lactide; ring-opening polymerization; kinetics; biodegradability |
