| 학회 |
한국재료학회 |
| 학술대회 |
2010년 가을 (11/11 ~ 11/12, 무주리조트) |
| 권호 |
16권 2호 |
| 발표분야 |
D. Health and Biological Materials(생체 및 의용재료) |
| 제목 |
Fabrication and characterization of DTBP Cross-linking PMMA/PCL fibrous scaffolds |
| 초록 |
Electrospinning has been used as simple and effective method to fabricated fibers with diameters ranging from micrometer to nanometer size. This process supplies high voltage to the tip of a syringe containing polymer solution and the fibers were collected by a metallic collector. The collected fibers generated 3D porous mats which can be applied in tissue engineering. It has high porosity and interconnectivity which can provide appropriate environment for favorable cell-material interactions. In this work, polycaprolactone (PCL) and polymethyl methacrylate (PMMA) were used to fabricate a scaffold for tissue engineering applications. PCL and PMMA solutions were mixed depending on various ratios and their microstructure and mechanical properties were evaluated. Dimethyl 3, 3-dithiobispropionimidate (DTBP) was used as chemical cross-linking agent to improve mechanical properties of the polymer. Crosslinked and uncrosslinked PMMA/PCL scaffolds were investigated by SEM. Tensile test was done to evaluate the mechanical property of the samples. Chemical properties were analyzed by differential scanning calorimetry (DSC) and FT-IR and contact-angle. Biological properties were investigated using cell attachment studies using L-929 fibroblast cell. |
| 저자 |
so-ra Son1, yang-hee Kim2, byong-taek Lee3
|
| 소속 |
1Department of Biomedical Engineering and Materials, 2School of Medicine, 3Soonchunhyang Univ. |
| 키워드 |
PMMA; PCL; ELECTROSPINNING; DTBP; CROSS-LINKING
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| E-Mail |
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