| 초록 |
It is well recognized that the pore size of polymer scaffolds plays an important role for cell adhesion, proliferation and differentiation: different kinds of cells were shown to have optimal pore size ranges in the scaffolds for effective cell adhesion/proliferation/differentiation. In recent, the scaffold with pore size gradient has been considered as a powerful tool for basic studies, including the investigation of the interactions between cells/tissues and scaffolds with different pore size, as well as the determination of optimum pore size range for stem cell differentiation to a specific cell type. In this study, we fabricated cylindrical PCL scaffolds with gradually increasing pore size ranges by a centrifugation method. Their morphology, pore size, porosity, and mechanical properties were investigated. The in vitro chondrogenic differentiation behavior of adipose-derived stem cells in terms of scaffold pore sizes were also investigated using the pore size gradient scaffold. |
