| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 가을 (10/11 ~ 10/12, 일산킨텍스) |
| 권호 |
32권 2호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Fabrication of hybrid nanoparticles by calcium phosphate mineralization on polymer micelle nanotemplates |
| 초록 |
Hybrid nanomaterials, particularly based on organic self-assemblies and inorganic calcium phosphates, have attracted much attention as novel drug carriers. In this study, we fabricated hybrid nanoparticles by calcium phosphate mineralization on polymer micelle nanotemplates of the core-shell-corona structure. Polymer micelles of PEG-b-Polyaspartate-b-polyphenylalanine (PEG-b-PAsp-b-PPhe) have successfully served as a nanotemplate for calcium phosphate mineralization. Calcium phosphate minerals on polymer micelles was formed by selective binding of Ca2+ ions on anionic polyaspartate middle layers of polymer micelles and subsequent addition of PO43- ions. Since a calcium phosphate layer on polymer micelles not only can increase stability of polymer micelles but also can be dissolved in endosomal pH and ionic conditions, the hybrid nanoparticle may have a potential as carriers for intracellular drug delivery. |
| 저자 |
이홍재1, 구안나1, 김찬우1, 김경자1, 박치영2, 김철희2, 이상천1
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| 소속 |
1요업(세라믹)기술원, 2인하대 |
| 키워드 |
calcium phosphate; mineralization; polymer micelle; hybrid; drug carrier
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| E-Mail |
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