| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 봄 (04/07 ~ 04/08, 대전컨벤션센터) |
| 권호 |
36권 1호 |
| 발표분야 |
International Symposium for Theranostic Macromolecules |
| 제목 |
Aptamer-mediated combined cancer imaging and therapy |
| 초록 |
A targeted drug delivery system of Dox to the prostate tumour based on PSMA-specific aptamer conjugated dendrimer will be presented. The Dox-loaded PSMA aptamer conjugated dendrimer exhibited excellent antitumor efficacy on in vivo prostate tumor models compared to control groups. In addition, I will present a multifunctional nanoparticle for targeted molecular CT imaging and therapy of prostate cancer. By functionalizing the surface of gold nanoparticles (GNPs) with a PSMA-specific A9 RNA aptamer, we established a targeted molecular CT imaging system capable of specific imaging of prostate cancer cells that express the PSMA protein. Furthermore, the aptamer-conjugated GNPs after loading of doxorubicin were significantly more potent against targeted LNCaP cells than against non-targeted PC3 cells. |
| 저자 |
전상용 |
| 소속 |
광주과학기술원 |
| 키워드 |
aptamer; nanoparticles; dendrimer; cancer imaging; drug delivery
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| E-Mail |
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