| 초록 |
A variety of nano-biomaterials, such as polymeric micelles, nanoparticles, and microparticles, have been studied for drug delivery, tissue engineering, and gene therapy. Biodegradable polymers and hydrogels containing bioactive molecules including protein drugs have been utilized for achieving sustained release and target-specific delivery. Self-assembled nano-scale micelles tagged with a cancer-targeting moiety on the surface were produced for actively targeting tumor cells. Recently, various inorganic/organic hybrid materials were synthesized for efficient intracellular delivery of antisense ODN, siRNA, and imaging agents into cells. We are particularly interested in self-assembled bio-mimetic nano-biomaterials useful for therapeutic and diagnostic applications. Synthetic polymers and biomolecules have been hybridized to create novel functional biomaterials. A series of new target-specific strategies for delivering therapeutic siRNA and imaging agents will be mainly introduced. |
