| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 봄 (04/07 ~ 04/08, 대전컨벤션센터) |
| 권호 |
36권 1호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Peroxalate copolymer nanoparticles for biomedical applications |
| 초록 |
Vanillin alcohol (VA) or hydroxybenzyl alcohol (HBA) is one of active pharmaceutical ingredients of Gastrodia elata, which has been a widely used herbal agent for the treatment of various inflammatory diseases. We have developed new biodegradable and anti-inflammatory peroxalate copolymers in which VA or HBA was incorporated into their backbone. The copolyoxalate was designed to release antioxidant and anti-inflammatory VA or HBA during hydrolytic degradation. Copolyoxalate was formulated into nanoparticles with an average diameter of 500 nm by a single emulsion method. VA or HBA-incorporated copolyoxalate scavenged hydrogen peroxide and inhibit the production of nitric oxide by suppressing the expression of inducible nitric oxide synthase in lipopolysaccharide-activated macrophages. The nanoparticles also inhibited the production of tumor necrosis factor-alph . We anticipate that HPOX is highly potent and versatile for the treatment of inflammatory diseases. |
| 저자 |
이동원, 홍동현, 송병주, 강길선
|
| 소속 |
전북대 |
| 키워드 |
biodegradable polymer; nanoparticles; drug delivery
|
| E-Mail |
|
