| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
38권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Preparation of folic acid-immobilized gold nanoparticles and their interaction with epithelial cancer cells |
| 초록 |
High quality, hydrophilic, uniform, and nontoxic mercaptosuccinic acid (M)-coated gold nanoparticles were prepared and characterized by TEM and DLS. M was used to improve the biocompatibility, monodispersity and non-specific intracellular uptake of nanoparticles. Folic acid (FA) was subsequently conjugated to the mercaptosuccinic acid -coated gold nanoparticles (MGNP) to preferentially target KB cells (epithelial cancer cells) those have folate receptors expressed on their membrane surfaces and facilitate the transit of nanoparticles across the cell membrane. Finally, fluorescence cyanine dye (Cy 5) was added to the nanoparticles to visualize the nanoparticle internalization into KB cells. After culture of the cells in a media containing the MGNP and FA- conjugated MGNP (FMGNP), the interaction of surface-modified gold nanoparticles with KB cells was studied. |
| 저자 |
피어슨 라씨나라, 칼리시 챈드라 굽타, 강인규
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| 소속 |
경북대 |
| 키워드 |
Gold nanoarticles; mercaptosuccinic acid; folic acid; molecular imaging
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| E-Mail |
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