| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 봄 (04/07 ~ 04/08, 대전컨벤션센터) |
| 권호 |
36권 1호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Effective sensitization of paclitaxel-resistant colorectal cancer cells by new cationic micelle-based combined delivery of paclitaxel and XIAP siRNA |
| 초록 |
Majority of anticancer drugs depend on the induction of apoptosis for cancer cell death. However, since expression of antiapoptotic proteins is significantly elevated in cancers, the efficiency of chemotherapy is often limited by the resistance mechanism. Simultaneous use of apoptosis-inducing drug and an inhibitor would address the drug resistance problems. Previously, we showed a conjugate of bile acid and polyethylenimine (PEI 1.8 KDa) formed cationic micelles and showed consistent cellular delivery of nucleic acid drugs such as siRNA. The paclitaxel-loaded cationic micelle was used for a combined delivery vehicle for siRNA. The siRNA silences the expression of antiapoptotic protein while paclitaxel induces apoptosis. The combination of an apoptosis inducer, paclitaxel, and siRNA targeting XIAP significantly increased the sensitivity of cancer cells for paclitaxel. The combined delivery system also demonstrated a desired synergic effect in an animal model bearing tumor xenograft. |
| 저자 |
장연림, 윤의정, 이민상, 김명구, 채수영, 정지훈
|
| 소속 |
성균관대 |
| 키워드 |
siRNA; cancer therapy; paclitaxel
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| E-Mail |
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