| 학회 | 한국화학공학회 |
| 학술대회 | 2006년 가을 (10/27 ~ 10/28, 고려대학교) |
| 권호 | 12권 2호, p.1802 |
| 발표분야 | 생물화공 |
| 제목 | pH-responsive behaviors of histidine-conjugated poly(amino acid) nanoparticles |
| 초록 | pH-responsive self-assembled nanoparticles of cationic graft copolymers based on histidine-conjugated poly(amino acid) derivatives in an aqueous solution was studied. Synthesized cationic copolymers formed self-assembled nanoparticles in an aqueous solution. pH-responsive behavior and physicochemical properties of nanoparticles in aqueous solution were extensively studied by light scattering, zeta potential, UV, pH-meter and TEM measurements. Because histidine moieties contain imidazole and α-amino group, whose pKa values are 6.04 and 9.33, it is expected that these self-assembled nanoparticles of cationic graft copolymers based on histidine-conjugated poly(amino acid) derivatives have a effective endosomolytic property and could escape endosome to deliver drug to the nucleus. |
| 저자 | 강윤정, 정재현, 김종득 |
| 소속 | 한국과학기술원 |
| 키워드 | pH-responsive; histidine; poly(amino acid) |
| 원문파일 | 초록 보기 |
