Single droplet experiments in a small lab scale Rotating Disk Contactor (RDC) for two different liquid-liquid systems were used to evaluate the coalescence parameters necessary for column simulations. Five different coalescence models are studied; the models parameters were obtained by an inverse solution of the population balance model using the extended fixed-pivot technique for the discretization of the droplet internal coordinate. The estimated coalescence parameters by solving the inverse problem were found dependent on the chemical test system. The Coulaloglou and Tavlarides model was found to be the best model to predict the experimental data for both test systems. These parameters were used to study the hydrodynamics and mass transfer behavior of pilot plant RDC extraction column using the simulation tool LLECMOD. This is performed for two different liquid-liquid systems as recommended by the European Federation of Chemical Engineering (EFCE) (butylacetate-acetone-water (b-a-w) and toluene-acetone-water (t-a-w)). The simulated Sauter mean droplet diameter, hold-up values and concentration profiles for organic and aqueous phase were found to be well predicted compared to the experimental data. (C) 2013 The Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved.