화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.22, 240-247, February, 2015
DOI10.1016/j.jiec.2014.07.016  Export Citation
Relative basicity approach for separation of a-toluic acid with triglycerides of fatty acids by reactive extraction
Kanti Kumar Athankar, Kailas L. Wasewar†, Mahesh N. Varma, and Diwakar Z. Shende
  • Advance Separation and Analytical Laboratory (ASAL), Department of Chemical Engineering, Visvesvaraya National Institute of Technology (VNIT), Nagpur 440010, MH, India
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Extraction of α-toluic acid from aqueous solution has drawn attention due to its ample range of biological, antibacterial, analgesic, and virucidal properties. In the present paper, reactive separation of α-toluic acid with tri-n-butyl phosphate dissolved in triglycerides of fatty acids such as castor oil, soybean oil and sunflower oil has been investigated to evaluate the performance of the diluents and extractants in reactive extraction process. The experimental results were presented as overall distribution coefficient (KD), loading factor (?), extraction efficiency (E%), and overall equilibrium constant (Eαβ) and observed in the range of data 4.4?45.7, 0.006?0.066, 81.6?97.9, and 15.1?28.1, respectively. Further relative basicity approach has been extended to represent the experimental results. The model is best suited to experimental results. The use of triglycerides of fatty acids (natural diluents) such as castor oil, soybean oil and sunflower oil can reduce the toxicity up to certain levels. Hence, all three diluents can be used to avoid the toxicity effect.
Keywords:Relative basicity;Extraction;a-Toluic acid;Triglycerides of fatty acids
  1. Wightman F, Lighty DL, Physiol. Plant., 55, 17 (1982)
  2. Leuba V, LeTorneau D, J. Plant Growth Regul., 9, 71 (1990)
  3. Van Balken JAM, Biotechnological Innovations in Chemical Synthesis, Butterworth-Heinemann, Oxford, 1997p. 158.
  4. Mohamed MS, Ismail W, Heider J, Fuchus G, Arch. Microbiol., 178, 180 (2002)
  5. Adams R, Thal AF, Org. Synth., 54, 655 (1932)
  6. Kaczmarek FS, Coykendall AL, J. Clin. Microbiol., 12, 288 (1980)
  7. Dai YY, King CJ, Ind. Eng. Chem. Res., 35(4), 1215 (1996)
  8. Pazouki M, Panda T, Bioprocess Eng., 19, 435 (1998)
  9. Paik WK, Han SB, Shin W, Kim YS, Langmuir, 19(10), 4211 (2003)
  10. Han SW, Joo SW, Ha TH, Kim Y, Kim K, J. Phys. Chem. B, 104(50), 11987 (2000)
  11. Leque R, Lin CSK, Du C, Macquarrie DJ, Koutinas A, Wang R, Webb C, Clark JH, Green Chem., 11, 193 (2009)
  12. Lee EG, Moon SH, Chang YK, Yoo IK, Chang HN, J. Membr. Sci., 145(1), 53 (1998)
  13. Wang ZX, Luo YB, Yu P, J. Membr. Sci., 280(1-2), 134 (2006)
  14. Cao X, Yun HS, Koo YM, Biochem. Eng. J., 11, 189 (2002)
  15. Sirman T, Pyle DL, Grandison AS, Biochem. Soc. Trans., 19, 274 (1991)
  16. Eyal AM, Bressler E, Biotechnol. Bioeng., 41, 287 (1993)
  17. King CJ, Starr J, US Patent US5,104,492 (1990).
  18. Timmer JM, Kromkamp J, Robbertsen T, J. Membr. Sci., 92(2), 185 (1994)
  19. Koops GH, Yamada S, Nakao SI, J. Membr. Sci., 189(2), 241 (2001)
  20. Rubio B, Escudero I, Ruiz MO, Cabezas JL, Alvarez JR, Coca J, Sep. Sci. Technol., 35(6), 811 (2000)
  21. Rodriguez M, Gonzalez-Munoz MJ, Luque S, Alvarez JR, Coca J, J. Membr. Sci., 274(1-2), 209 (2006)
  22. Malmary G, Vezier A, Robert A, Mourgues J, Conte T, Molinier J, J. Chem. Technol. Biotechnol., 60(1), 67 (1994)
  23. Jaquet A, Quan I, Marision IW, Stockar UV, J. Biotechnol., 68, 185 (1999)
  24. King CJ, Chem. Technol., 5, 285 (1992)
  25. Tamada JA, Kertes AS, King CJ, Ind. Eng. Chem. Res., 29, 1319 (1990)
  26. Solichien MS, Obrien D, Hammond EG, Glatz CE, Enzyme Microb. Technol., 17(1), 23 (1995)
  27. Lanne C, Boeren S, Vos K, Trends Biotechnol., 3, 251 (1985)
  28. Gu Z, Glatz BA, Glatz CE, Biotechnol. Bioeng., 57(4), 454 (1998)
  29. Roffler SR, Randolph TW, Miller DA, Blanch HW, Prausnitz JM, in: Mattiasson B, Holst O (Eds.), Extractive Bioconversions, Marcel Dekker Inc., New York, 1991, p. 135.
  30. Wasewar KL, Heesink ABM, Versteeg GF, Pangarkar VG, J. Chem. Technol. Biotechnol., 77(9), 1068 (2002)
  31. Wasewar KL, Pangarkar VG, Heesink ABM, Versteeg GF, Chem. Eng. Sci., 58(15), 3385 (2003)
  32. Wasewar KL, Heesink ABM, Versteeg GF, Pangarkar VG, Chem. Eng. Sci., 59(11), 2315 (2004)
  33. Keshav A, Wasewar KL, Chand S, Chem. Biochem. Eng. Q., 22, 433 (2008)
  34. Keshav A, Wasewar KL, Chand S, Chem. Eng. Commun., 197(4), 606 (2010)
  35. Keshav A, Norge P, Wasewar KL, Appl. Biochem. Biotechnol., 167(2), 197 (2012)
  36. Wasewar KL, Shende DZ, J. Chem. Eng. Data, 55(9), 4121 (2010)
  37. Wasewar KL, Shende DZ, J. Chem. Eng. Data, 56(8), 3318 (2011)
  38. Wasewar KL, Shende D, Keshav A, Ind. Eng. Chem. Res., 50(2), 1003 (2011)
  39. Wasewar KL, Shende D, Keshav A, J. Chem. Technol. Biotechnol., 86(2), 319 (2011)
  40. Waghmare MD, Wasewar KL, Sonawane SS, Shende DZ, Ind. Eng. Chem. Res., 50(23), 13526 (2011)
  41. Waghmare MD, Wasewar KL, Sonawane SS, Shende DZ, Sep. Purif. Technol., 120, 296 (2013)
  42. Datta D, Kumar S, Ind. Eng. Chem. Res., 50(5), 3041 (2011)
  43. Inci I, Uslu H, J. Chem. Eng. Data, 50(2), 536 (2005)
  44. Tuyun AF, Uslu H, J. Chem. Eng. Data, 57(1), 190 (2012)
  45. Uslu H, J. Chem. Eng. Data, 57(3), 902 (2012)
  46. Kloetzer L, Postaru M, Galaction AI, Blaga AC, Cascaval D, Ind. Eng. Chem. Res., 52, 13785 (2013)
  47. Gaidhani HK, Wasewar KL, Pangarkar VG, Chem. Eng. Sci., 57(11), 1979 (2002)
  48. Athankar KK, Varma MN, Shende DZ, Yoo CK, Wasewar KL, J. Chem. Eng. Data, 58(11), 3240 (2013)
  49. Binder RG, Applewhite TH, Kohler GO, Goldblatt LA, J. Am. Oil Chem. Soc., 39, 513 (1962)
  50. Collins FI, Sedgwick VE, J. Am. Oil Chem. Soc., 36, 641 (1959)
  51. Lajra JR, Diaz U, Quidiello RD, J. Am. Oil Chem. Soc., 67, 618 (1990)
  52. Brandani S, Brandani V, Veglio F, Ind. Eng. Chem. Res., 37(1), 292 (1998)
  53. Kertes AS, King CJ, Biotechnol. Bioeng., 28, 269 (1986)
  54. Dippy JFJ, Hughes SRC, Rozanski A, J. Chem. Soc., http://dx.doi.org/10.1039/JR9590002492., 2492 (1959)
  55. Nernst W, Ztschr. Phys. Chem., 8, 110 (1891)
  56. Shan XC, Bachelor Thesis, Tsinghua University, 2003.
  57. Shan XC, Qin W, Dai YY, Chem. Eng. Sci., 61(8), 2574 (2006)