Electrospun badger (Meles meles) oil/Ag nanoparticle based anti-bacterial mats for biomedical applications

Jun Hee Kim; Arjun Prasad Tiwari; Han Joo Kim; Afeesh Rajan Unnithan; Chan Hee Park; Cheol Sang Kim

Journal of Industrial and Engineering Chemistry, Vol.30, 254-260, October, 2015

DOI10.1016/j.jiec.2015.05.030 Export Citation

Electrospun badger (Meles meles) oil/Ag nanoparticle based anti-bacterial mats for biomedical applications

Jun Hee Kim¹, Arjun Prasad Tiwari¹, Han Joo Kim¹, Afeesh Rajan Unnithan^{1, 2}, Chan Hee Park^{1, 2, †}, and Cheol Sang Kim^{1, 2, †}

¹Department of Bio-nano System Engineering, Chonbuk National University, Jeonju 561-756, Republic of Korea
²Division of Mechanical Design Engineering, Chonbuk National University, Jeonju 561-756, Republic of Korea

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In this study, silver nanoparticles and badger oil were embedded into nanofibrous polyurethane (PU) mats via electrospinning. Badger oil is mainly composed of fatty acids and is used as a traditional medicine to heal wounds and the silver nanoparticles contribute to the wound healing process by reducing wound contamination. The composite mats exhibited good bactericidal activity against both of Gram positive and Gram negative bacteria, with better cell attachment and proliferation. The results of this study indicate that the proposed composite mats can be used for various biomedical purposes, including as dressings for burn wounds or to treat skin disease.

Keywords:Nanofibers;Nano-structures;Particle-reinforcement;Electrospinning;Wound dressing

[References]

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Zahedi P, Rezaeian I, Ranaei-Siadat SO, Jafari SH, Supaphol P, Polym. Adv. Technol., 21, 77 (2010)
Unnithan AR, Pichiah PBT, Gnanasekaran G, Seenivasan K, Barakat NAM, Cha YS, Jung CH, Shanmugam A, Kim HY, Colloids Surf. A: Physicochem. Eng. Asp., 415, 454 (2012)
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Chithra P, Sajithlal GB, Chandrakasan G, J. Ethnopharmacol., 59, 195 (1998)
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Sheikh FA, Barakat NAM, Kanjwal MA, Chaudhari AA, Jung IH, Lee JH, Kim HY, Macromol. Res., 17(9), 688 (2009)
Barakat NAM, Kanjwal MA, Sheikh FA, Kim HY, Polymer, 50(18), 4389 (2009)
Jiang Z, Yuan KJ, Li SF, Chow WK, Guang pu xue yu guang pu fen xi=Guang pu, 26, 624 (2006)
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[1] Kamel RA, Ong JF, Eriksson E, Junker JPE, Caterson EJ, J. Am. Coll. Surg., 217, 533 (2013)

[2] Hogge J, Krasner D, Nguyen H, Harkless LB, Armstrong DG, J. Am. Podiatr. Med. Assoc., 90, 57 (2000)

[3] O’Meara S, Cullum N, Majid M, Sheldon T, Health Technol. Assess., 4, 1 (2000)

[4] Zahedi P, Rezaeian I, Ranaei-Siadat SO, Jafari SH, Supaphol P, Polym. Adv. Technol., 21, 77 (2010)

[5] Unnithan AR, Pichiah PBT, Gnanasekaran G, Seenivasan K, Barakat NAM, Cha YS, Jung CH, Shanmugam A, Kim HY, Colloids Surf. A: Physicochem. Eng. Asp., 415, 454 (2012)

[6] Amina M, Amna T, Hassan MS, Ibrahim TA, Khil MS, Colloids Surf. A: Physicochem. Eng. Asp., 425, 115 (2013)

[7] Leach MJ, Ostomy/Wound Manage., 50, 36 (2004)

[8] Bodeker GC, Ryan TJ, Ong CK, Clin. Dermatol., 17, 93 (1999)

[9] Chithra P, Sajithlal GB, Chandrakasan G, J. Ethnopharmacol., 59, 195 (1998)

[10] Saha K, Mukherjee PK, Das J, Pal M, Saha BP, J. Ethnopharmacol., 56, 139 (1997)

[11] Villegas LF, Fernandez ID, Maldonado H, Torres R, Zavaleta A, Vaisberg AJ, Hammond GB, J. Ethnopharmacol., 55, 193 (1997)

[12] Zalewski K, Martysiak-Zurowska D, Iwaniuk M, Nitkiewicz B, Stolyhwo A, Pol. J. Environ. Stud., 16, 645 (2007)

[13] Desbois AP, Smith VJ, Appl. Microbiol. Biotechnol., 85(6), 1629 (2010)

[14] Kim JS, Kuk E, Yu KN, Kim JH, Park SJ, Lee HJ, Kim SH, Park YK, Park YH, Hwang CY, Kim YK, Lee YS, Jeong DH, Cho MH, Nanomed.-Nanotechnol. Biol. Med., 3, 95 (2007)

[15] Wei D, Sun W, Qian W, Ye Y, Ma X, Carbohydr. Res., 344, 2375 (2009)

[16] Akhavan O, Ghaderi E, Surf. Coat. Technol., 204, 3676 (2010)

[17] Bryaskova R, Pencheva D, Kale GM, Lad U, Kantardjiev T, J. Colloid Interface Sci., 349(1), 77 (2010)

[18] Chun JY, Kang HK, Jeong L, Kang YO, Oh JE, Yeo IS, Jung SY, Park WH, Min BM, Colloids Surf. B: Biointerfaces, 78, 334 (2010)

[19] Jin WJ, Jeon HJ, Kim JH, Youk JH, Synth. Met., 157, 454 (2007)

[20] Reneker DH, Chun I, Nanotechnology, 7, 216 (1996)

[21] Rieger KA, Birch NP, Schiffman JD, J. Mater. Chem. B, 1, 4531 (2013)

[22] Zhang Y, Lim CT, Ramakrishna S, Huang ZM, J. Mater. Sci. -Mater. Med., 16, 933 (2005)

[23] Pastoriza-Santos I, Liz-Marzan LM, Langmuir, 15(4), 948 (1999)

[24] Sheikh FA, Barakat NAM, Kanjwal MA, Chaudhari AA, Jung IH, Lee JH, Kim HY, Macromol. Res., 17(9), 688 (2009)

[25] Barakat NAM, Kanjwal MA, Sheikh FA, Kim HY, Polymer, 50(18), 4389 (2009)

[26] Jiang Z, Yuan KJ, Li SF, Chow WK, Guang pu xue yu guang pu fen xi=Guang pu, 26, 624 (2006)

[27] Choi O, Hu Z, Environ. Sci. Technol., 42, 4583 (2008)