The indirect coal to liquids (CTL) plant based on gasification and Fischer-Tropsch (FT) technology is technically feasible, but it is plagued with high CO2 emission in comparison to the petroleum-based fuel production processes. Addition of a moderate amount of biomass to the feed and inclusion of CO2 capture and storage (CCS) technology to the indirect CTL process can reduce its environmental footprint, but at the cost of higher capital investment as well as larger operational penalty. In this study, a techno-economic analysis of a novel indirect coal-biomass to liquids (CBTL) plant with CCS is performed using Aspen Process Economic Analyzer based on a process model developed in Aspen Plus. This paper has evaluated the impact of key investment parameters, such as raw material cost, project contingency, and process capacity, on the economic measures, including net present value, internal rate of return, payback period, and break-even oil price. In addition, the impacts of technology choices for product upgrading and carbon capture and the effects of key design parameters, such as coal/biomass ratio, type of biomass, extent of CO2 capture, and H-2/CO ratio in the FT inlet stream, are evaluated. Impact of current crude oil prices on the feasibility of CBTL plants is also evaluated.