In this work, cobalt-nickel oxide nanorods decorated molybdenum disulfide nanosheets (NiCo2O4-MoS2) nanocomposite material was synthesized by a simple ionothermal synthesis method in deep eutectic solvents, after which, a glucose sensor based on the (NiCo2O4-MoS2) nanocomposites was constructed. The nanocomposite material was characterized by X-ray diffractometer (XRD), X-ray photoelectron spectroscopy (XPS) and scanning electron microscope (SEM). At the potential of +0.5823 V (vs. NHE), the electrochemical response of the sensor was linear with the glucose concentration ranging from 0.70 mu M to 13.78 mM and the sensor exhibited excellent electrocatalytic performance toward the oxidation of glucose with a low detection limit of 0.23 mu M (S/N = 3). In addition, it also has a good selectivity, stability, repeatability and reproducibility. Furthermore, the sensor was used to detect the glucose in honey and red wine. All of these suggested that the NiCo2O4-MoS2 nanocomposites might be promising candidate nanomaterials for constructing electrochemical sensors to detect glucose. (C) 2019 The Electrochemical Society.