Titanium(IV) isopropoxide (TTIP) is an important precursor for the production of nanoparticles by spray flame processes. In these processes, the precursor is provided in a solution in a combustible solvent, which is p-xylene here. As no thermophysical data for solutions of TTIP in p-xylene were available in the literature, they were measured in the present work. The vapor-liquid equilibrium was measured at pressures ranging from 20 to 80 kPa. The specific density, viscosity, thermal conductivity, molar isobaric heat capacity, and self-diffusion coefficients were determined experimentally at 101.3 kPa at temperatures between 293.15 and 373.15 K. Sample compositions cover the range from pure TTIP to pure p-xylene. Chemical reactions in the studied system were considered. The experiments were carried out in such a way that they do not compromise the results for the thermophysical properties. The vapor-liquid equilibrium data were correlated using the NRTL model. Empirical correlations were established for the other properties. The results provide a rational basis for spray flame process design.